Increasing Novel Vocalizations for Individuals with ASD Using a Voice Output Communication Aide

This study aimed to extend the literature on VOCA as a means of producing increased verbal speech using a prompt delay and shaping methods. Intervention targeted novel vocalization for three children with autism spectrum disorder (ASD) and limited vocal speech. All three participants increased vocalizations, but to varying degrees and only after a second phase where an echoic prompt was introduced. While the results vary across participants, increased vocal speech for all participants and high social validity suggest that VOCA-based interventions may be an appropriate intervention to increase vocal output for children with ASD

Whiskerless Schottky diode

A Schottky diode for millimeter and submillimeter wave applications is comprised of a multi-layered structure including active layers of gallium arsenide on a semi-insulating gallium arsenide substrate with first and second insulating layers of silicon dioxide on the active layers of gallium arsenide. An ohmic contact pad lays on the silicon dioxide layers. An anode is formed in a window which is in and through the silicon dioxide layers. An elongated contact finger extends from the pad to the anode and a trench, preferably a transverse channel or trench of predetermined width, is formed in the active layers of the diode structure under the contact finger. The channel extends through the active layers to or substantially to the interface of the semi-insulating gallium arsenide substrate and the adjacent gallium arsenide layer which constitutes a buffer layer. Such a structure minimizes the effect of the major source of shunt capacitance by interrupting the current path between the conductive layers beneath the anode contact pad and the ohmic contact. Other embodiments of the diode may substitute various insulating or semi-insulating materials for the silicon dioxide, various semi-conductors for the active layers of gallium arsenide, and other materials for the substrate, which may be insulating or semi-insulating

A Lexicalized Tree Adjoining Grammar for English

This paper presents a sizable grammar for English written in the Tree Adjoining grammar (TAG) formalism. The grammar uses a TAG that is both lexicalized (Schabes, Abeillé, Joshi 1988) and feature-based (Vijay-Shankar, Joshi 1988). In this paper, we describe a wide range of phenomena that it covers. A Lexicalized TAG (LTAG) is organized around a lexicon, which associates sets of elementary trees (instead of just simple categories) with the lexical items. A Lexicalized TAG consists of a finite set of trees associated with lexical items, and operations (adjunction and substitution) for composing the trees. A lexical item is called the anchor of its corresponding tree and directly determines both the tree\u27s structure and its syntactic features. In particular, the trees define the domain of locality over which constraints are specified and these constraints are local with respect to their anchor. In this paper, the basic tree structures of the English LTAG are described, along with some relevant features. The interaction between the morphological and the syntactic components of the lexicon is also explained. Next, the properties of the different tree structures are discussed. The use of S complements exclusively allows us to take full advantage of the treatment of unbounded dependencies originally presented in Joshi (1985) and Kroch and Joshi (1985). Structures for auxiliaries and raising-verbs which use adjunction trees are also discussed. We present a representation of prepositional complements that is based on extended elementary trees. This representation avoids the need for preposition incorporation in order to account for double wh-questions (preposition stranding and pied-piping) and the pseudo-passive. A treatment of light verb constructions is also given, similar to what Abeillé (1988c) has presented. Again, neither noun nor adjective incorporation is needed to handle double passives and to account for CNPC violations in these constructions. TAG\u27S extended domain of locality allows us to handle, within a single level of syntactic description, phenomena that in other frameworks require either dual analyses or reanalysis. In addition, following Abeillé and Schabes (1989), we describe how to deal with semantic non compositionality in verb-particle combinations, light verb constructions and idioms, without losing the internal syntactic composition of these structures. The last sections discuss current work on PRO, case, anaphora and negation, and outline future work on copula constructions and small clauses, optional arguments, adverb movement and the nature of syntactic rules in a lexicalized framework

Divergent Eddy Heat Fluxes in the Kuroshio Extension at 144°–148°E. Part I: Mean Structure

The Kuroshio Extension System Study (KESS) provided 16 months of observations to quantify eddy heat flux (EHF) from a mesoscale-resolving array of current- and pressure-equipped inverted echo sounders (CPIES). The mapped EHF estimates agreed well with point in situ measurements from subsurface current meter moorings. Geostrophic currents determined with the CPIES separate the vertical structure into an equivalent-barotropic internal mode and a nearly depth-independent external mode measured in the deep ocean. As a useful by-product of this decomposition, the divergent EHF (DEHF) arises entirely from the correlation between the external mode and the upper-ocean thermal front. EHFs associated with the internal mode are completely rotational. DEHFs were mostly downgradient and strongest just upstream of a mean trough at ~147°E. The downgradient DEHFs resulted in a mean-to-eddy potential energy conversion rate that peaked midthermocline with a magnitude of 10 × 10−3 cm2 s−3 and a depth-averaged value of 3 × 10−3 cm2 s−3. DEHFs were vertically coherent, with subsurface maxima exceeding 400 kW m−2 near 400-m depth. The subsurface maximum DEHFs occurred near the depth where the quasigeostrophic potential vorticity lateral gradient changes sign from one layer to the next below it. The steering level is deeper than this depth of maximum DEHFs. A downgradient parameterization could be fitted to the DEHF vertical structure with a constant eddy diffusivity κ that had values of 800–1400 m2 s−1 along the mean path. The resulting divergent meridional eddy heat transport across the KESS array was 0.05 PW near 35.25°N, which may account for ~⅓ of the total Pacific meridional heat transport at this latitude

Source of Lake Vostok Cations Constrained with Strontium Isotopes

Lake Vostok is the largest sub-glacial lake in Antarctica. The primary source of our current knowledge regarding the geochemistry and biology of the lake comes from the analysis of refrozen lake water associated with ice core drilling. Several sources of dissolved ions and particulate matter to the lake have been proposed, including materials from the melted glacier ice, the weathering of underlying geological materials, hydrothermal activity and underlying, ancient evaporitic deposits. A sample of Lake Vostok Type 1 accretion ice has been analyzed for its 87Sr/86Sr signature as well as its major cation and anion and Sr concentrations. The strontium isotope ratio of 0.71655 and the Ca/Sr ratio in the sample strongly indicate that the major source of the Sr is from aluminosilicate minerals from the continental crust. These data imply that at least a portion of the other cations in the Type 1 ice also are derived from continental crustal materials and not hydrothermal activity, the melted glacier ice, or evaporitic sources

Wellness and Multiple Sclerosis: The National MS Society Establishes a Wellness Research Working Group and Research Priorities

Background: People with multiple sclerosis (MS) have identified “wellness” and associated behaviors as a high priority based on “social media listening” undertaken by the National MS Society (i.e. the Society). Objective: The Society recently convened a group that consisted of researchers with experience in MS and wellness-related research, Society staff members, and an individual with MS for developing recommendations regarding a wellness research agenda. Method: The members of the group engaged in focal reviews and discussions involving the state of science within three approaches for promoting wellness in MS, namely diet, exercise, and emotional wellness. Results: That process informed a group-mediated activity for developing and prioritizing research goals for wellness in MS. This served as a background for articulating the mission and objectives of the Society’s Wellness Research Working Group. Conclusion: The primary mission of the Wellness Research Working Group is the provision of scientific evidence supporting the application of lifestyle, behavioral, and psychosocial approaches for promoting optimal health of mind, body, and spirit (i.e. wellness) in people with MS as well as managing the disease and its consequences

Establishment of early donor engraftment after reduced-intensity allogeneic hematopoietic stem cell transplantation to potentiate the graft-versus-lymphoma effect against refractory lymphomas

AbstractReduced-intensity allogeneic hematopoietic stem cell transplantation (alloHSCT), which typically results in mixed chimerism initially after transplantation, has had limited efficacy in chemotherapy-refractory lymphomas. We hypothesized that the rapid establishment of complete donor chimerism would potentiate a graft-versus-lymphoma effect. Fifteen patients with chemotherapy-refractory lymphoma initially received induction with a conventional chemotherapy regimen (etoposide, prednisone, vincristine, cyclophosphamide, adriamycin, fludarabine [EPOCH-F]) to deplete host T cells and provide disease control prior to alloHSCT. Patients then received conditioning with fludarabine and cyclophosphamide followed by alloHSCT from HLA-matched siblings. Graft-versus-host disease prophylaxis consisted of cyclosporine alone. EPOCH-F resulted in 73% of patients having partial responses or stable disease. EPOCH-F depleted host CD4+ T cells from a median of 235 cells/μL to 56 cells/μL. Fourteen patients underwent alloHSCT, and all had >95% donor engraftment by day 14 after transplantation. The incidence of Grade II to III acute graft-versus-host disease was 71%. There were two therapy-related deaths. There were 8 partial responses and 3 complete responses (CRs) at day 28. Five additional CRs were observed at day 100 without withdrawal of cyclosporine or donor lymphocyte infusion. The rate of CRs for all 15 patients was 60%. The 1-year progression-free survival rate from time of study entry is 67% with only 1 relapse among 9 CRs. At a median potential follow-up of 28 months, the overall survival rate is 53%. These data demonstrate that a potent and durable graft-versus-lymphoma effect can occur against chemotherapy-refractory lymphomas and suggest that this effect may be associated with rapid, complete donor chimerism after reduced-intensity alloHSCT. © 2003 American Society for Blood and Marrow TransplantationBiology of Blood and Marrow Transplantation 9:162-169 (2003